遗传修饰小鼠
在GB遗传修饰小鼠,也称作基因工程小鼠,也叫遗传工程小鼠(Genetically Engineered Mouse Models),是指通过基因工程技术手段,对小鼠基因组进行一定的人为修饰,由此产生具有特定表型或特征的小鼠。 是研究基因功能、人类疾病的最主要的动物模型。
下面的资源只是列举了部分,不一定准确。欢迎大家讨论,修订。
1. 国内
1.1 科研院所和高校建立
- 清华大学实验动物中心:http://www.larc.tsinghua.edu.cn/category/AboutUs/Services
- 北京大学实验动物中心:https://www.lac.pku.edu.cn/jzfw1/ptjzpt/index.htm
- 中科院动物所实验动物中心:http://lac.ioz.ac.cn/jsfw/jybjdwmxdz/crispr/
- 苏州大学剑桥-苏大基因组资源中心(CAM-SU GRC):https://www.cam-su.cn
1.2 常用公司
- 江苏集萃药康生物科技股份有限公司:https://www.gempharmatech.com
- 上海南方模式生物科技股份有限公司:www.modelorg.com
- 赛业(广州)生物科技有限公司:https://www.cyagen.com/cn/zh-cn
2. 国外
2.1 资源整合和查询数据库
- European Mouse Mutant Archive (EMMA): www.infrafrontier.eu
- Mutant Mouse Regional Resource Centers (MMRRC):www.mmrrc.org
- RIKEN:https://mus.brc.riken.jp/en
- International Mouse Strain Resource (IMSR):www.findmice.org
- Knockout Mouse Project (KOMP): www.knockoutmouse.org
2.2 科研院所和高校建立
- Johns Hopkins Univ. Transgenic Core Laboratory:www.hopkinsmedicine.org/core/home.htm
- U Wash. Transgenic Resources Program:https://www.washington.edu/research/shared-research-facilities-resources/transgenic-resources-program-trp/
- U Penn. Transgenic & Chimeric Mouse Facility:https://genetics.med.upenn.edu/cores/tcmf
- Washington University Mouse Genetics Core:https://mousegeneticscore.wustl.edu/
- University of Michigan Transgenic Animal Model Core:https://medresearch.umich.edu/office-research/about-office-research/biomedical-research-core-facilities/transgenic-animal-model
- UCLA Cedars-Sinai Rodent Genetics Core:https://www.cedars-sinai.edu/research-education/research/cores/rodent-genetics.html
- Duke University Transgenic Mouse Facility:http://www.tmf.cancer.duke.edu
- Yale University Animal Genomics Services:https://medicine.yale.edu/compmed/ags/
- Stanford University Transgenic Mouse Research Facility:https://med.stanford.edu/tktc.html
- University of Connecticut Gene Targeting and Transgenic Facility:https://health.uconn.edu/mouse-genome-modification/services
- UNC Chapel Hill Animal Model Core:https://www.med.unc.edu/corefacilities/core-listings-by-categories/animal-models/
- VCU Transgenic Mouse Core Facility:https://www.masseycancercenter.org/research/shared-resource-cores/transgenic-knock-out-mouse-shared-resource
- The Genetically Engineered Murine Model (GEMM) Core at UVA:https://med.virginia.edu/genetically-engineered-murine-model-core/
2.3 常用公司
- The Jackson Lab:https://www.jax.org
- Taconic:https://www.taconic.com
- Charles River Lab:https://www.criver.com