遗传修饰小鼠

在GB遗传修饰小鼠，也称作基因工程小鼠，也叫遗传工程小鼠（Genetically Engineered Mouse Models），是指通过基因工程技术手段，对小鼠基因组进行一定的人为修饰，由此产生具有特定表型或特征的小鼠。 是研究基因功能、人类疾病的最主要的动物模型。

科研院所和高校建立

国外内

• 清华大学实验动物中心：http://www.larc.tsinghua.edu.cn/category/AboutUs/Services
• 北京大学实验动物中心：https://www.lac.pku.edu.cn/jzfw1/ptjzpt/index.htm
• 中科院动物所实验动物中心：http://lac.ioz.ac.cn/jsfw/jybjdwmxdz/crispr/

国外

• Johns Hopkins Univ. Transgenic Core Laboratory：www.hopkinsmedicine.org/core/home.htm
• U Wash. Transgenic Resources Program：https://www.washington.edu/research/shared-research-facilities-resources/transgenic-resources-program-trp/
• U Penn. Transgenic & Chimeric Mouse Facility：https://genetics.med.upenn.edu/cores/tcmf
• Washington University Mouse Genetics Core：https://mousegeneticscore.wustl.edu/
• University of Michigan Transgenic Animal Model Core：https://medresearch.umich.edu/office-research/about-office-research/biomedical-research-core-facilities/transgenic-animal-model
• UCLA Cedars-Sinai Rodent Genetics Core：https://www.cedars-sinai.edu/research-education/research/cores/rodent-genetics.html
• Duke University Transgenic Mouse Facility：http://www.tmf.cancer.duke.edu
• Yale University Animal Genomics Services：https://medicine.yale.edu/compmed/ags/
• Stanford University Transgenic Mouse Research Facility：https://med.stanford.edu/tktc.html
• University of Connecticut Gene Targeting and Transgenic Facility：https://health.uconn.edu/mouse-genome-modification/services
• UNC Chapel Hill Animal Model Core：https://www.med.unc.edu/corefacilities/core-listings-by-categories/animal-models/
• VCU Transgenic Mouse Core Facility：https://www.masseycancercenter.org/research/shared-resource-cores/transgenic-knock-out-mouse-shared-resource
• The Genetically Engineered Murine Model (GEMM) Core at UVA：https://med.virginia.edu/genetically-engineered-murine-model-core/